Alkylating agents were one of the first classes of drugs

What drugs are alkylating agents?

  • Altretamine.
  • Bendamustine.
  • Busulfan.
  • Carboplatin.
  • Carmustine.
  • Chlorambucil.
  • Cisplatin.
  • Cyclophosphamide.

What is an alkylating drug?

OVERVIEW. Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby stopping the protein synthesis.

What is the example of alkylating agent?

Some examples of alkylating agents are nitrogen mustards (chlorambucil and cyclophosphamide), cisplatin, nitrosoureas (carmustine, lomustine, and semustine), alkylsulfonates (busulfan), ethyleneimines (thiotepa), and triazines (dacarbazine).

Which anticancer drug is an alkylating agent?

Cyclophosphamide — the most widely used alkylating agent of modern times.

What chemical reaction do alkylating agents participate in?

The alkylating agents are a group of strong disinfecting chemicals that act by replacing a hydrogen atom within a molecule with an alkyl group (CnH2n+1), thereby inactivating enzymes and nucleic acids (Figure 13.3. 11).

Is Adriamycin an alkylating agent?

Also called Adriamycin PFS, Adriamycin RDF, doxorubicin hydrochloride, hydroxydaunorubicin and Rubex. A medicine used to treat many types of cancer and being studied in treatment of other types of cancer. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.

Is Methotrexate an alkylating agent?

Cyclophosphamide, azathioprine, chlorambucil, and methotrexate are cytotoxic drugs used most commonly for the purpose of immunosuppression. Cyclophosphamide and chlorambucil are alkylating agents, which cause cross-linking of DNA resulting in altered protein production, decreased cell division, and cell death.

Which drug is not an alkylating agent?

Note: Although the platinum-containing anticancer agents, carboplatin, cisplatin, and oxaliplatin are frequently classified as alkylating agents, they are not.

Is carboplatin an alkylating agent?

Carboplatin is an intravenously administered platinum coordination complex and alkylating agent which is used as a chemotherapeutic agent for the treatment of various cancers, mainly ovarian, head and neck and lung cancers.

Article first time published on

Is cyclophosphamide an alkylating agent?

Cyclophosphamide is in a class of medications called alkylating agents. When cyclophosphamide is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When cyclophosphamide is used to treat nephrotic syndrome, it works by suppressing your body’s immune system.

Which of these are examples of alkylating agents quizlet?

  • Nitrogen mustard.
  • Alkylsulfonates.
  • Nitrosoureas.
  • Triazines.
  • Ethylenimines.
  • Methylhyderazine.

Is oxaliplatin an alkylating agent?

Oxaliplatin is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell-cycle non-specific. There are several types of alkylating agents.

What are the classical alkylating agents?

Alkylating agents in the classic family include nitrogen mustard, cyclophosphamide, chlorambucil, melphalan, busulfan, and ifosfamide.

Is cisplatin an alkylating agent?

Cisplatin is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell.

Is mitomycin C an alkylating agent?

Mitomycin (28.1. 110) is an antineoplastic antibiotic against a wide variety of cancer types produced by Streptomyces caespitosus. It is an important antitumor compound, and being an alkylating agent, has an extraordinary ability to crosslink DNA with high efficiency.

What drug is AC?

AC is a combination of two chemotherapy drugs used to treat breast cancer. It takes its name from the initials of these drugs: doxorubicin (also known as Adriamycin) cyclophosphamide.

What is taxol used for in medicine?

Paclitaxel is used to treat various types of cancer. It is a cancer chemotherapy drug that works by slowing or stopping cancer cell growth.

Which type of alkylating agent is mostly used in the form of gas?

Nitrogen Mustards. The most frequently used alkylating agents are the nitrogen mustards. Although thousands of nitrogen mustards have been synthesized and tested, only five are commonly used in cancer therapy today.

What are bifunctional alkylating agents?

Bifunctional alkylating agents, such as chlorambucil or BCNU, are commonly used anticancer drugs. DNA lesions produced by these agents require complex repair mechanisms.

What cyclophosphamide is used for?

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).

Is dacarbazine an alkylating agent?

Dacarbazine is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell-cycle non-specific.

What type of agent is methotrexate?

Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.

What is an alkylating agent in chemotherapy?

Alkylating agents were among the first anti-cancer drugs and are the most commonly used agents in chemotherapy today. Alkylating agents act directly on DNA, causing cross-linking of DNA strands, abnormal base pairing, or DNA strand breaks, thus preventing the cell from dividing.

Is Alimta a chemotherapy drug?

It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

Why is Taxol given before carboplatin?

Taxol (paclitaxel, Paxel) must be given before carboplatin because if carboplatin is given before Taxol, it stops Taxol from having an effect on cancer cells. This is called a scheduling interaction because when Taxol is given before carboplatin, there is little interaction and both agents work as intended.

Is chlorambucil an alkylating agent?

Chlorambucil is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell cycle non-specific. There are several types of alkylating agents.

What kind of drug is doxorubicin?

Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow. You might have doxorubicin in combination with other chemotherapy drugs.

What drugs are antimetabolites?

  • 6-mercaptopurine.
  • fludarabine.
  • 5-fluorouracil.
  • gemcitabine.
  • cytarabine.
  • pemetrexed.
  • methotrexate.

What drugs are known to cause alopecia select all that apply?

  • adriamycin.
  • cyclophosphamide.
  • dactinomycin.
  • daunorubicin.
  • docetaxel.
  • doxorubicin.
  • etoposide.
  • fluorouracil.

Which of the following is an antibiotic antitumor?

The antitumor antibiotics consist of dactinomycin, adriamycin, bleomycin, mithramycin, and mitomycin-C.